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Allogeneic bone marrow or stem cell transplant
An allogeneic stem cell transplant, also known as a bone marrow transplant, is used to treat blood cancers and disorders using matched donor cells
About allogeneic transplants
Transplantation is the transfer of living tissue or organs from one part of the body to another from one individual to another. When stem cells are donated by another person (a donor), it is called an allogeneic transplant or an allograft. An allogeneic transplant or allograft involves the infusion of bone marrow or stem cells where people have similar genetic tissue.
Depending on the type of treatment you are having, the transplant works by delivering high doses of chemotherapy and/or radiotherapy to destroy any remaining diseased or malignant cells in your body. The high-dose treatment is given to increase the probability of the disease responding to treatment, but in doing so it destroys both cancer cells and healthy blood cells. The cells in the bone marrow are especially affected, resulting in decreased numbers of red blood cells, white blood cells and platelets, which increases the chance of infection, anaemia and bleeding.
The transfer of bone marrow or stem cells provides you with a source of healthy bone marrow, which will also help you to recover from the effects of the high-dose treatment. It essentially ‘rescues’ you with new bone marrow or stem cell tissue, which travels to the bone marrow spaces in your bones, grows and begins to produce new blood cells. This engraftment (growth) is reflected in your blood counts, which should gradually increase over several weeks.
What happens when you have an allogeneic transplant
Collecting stem cells from your donor
Blood tests or ‘tissue typing’ will have been performed in order to select a high match donor. This may be from a sibling or close relative or from an unrelated donor who has chosen to donate to The British Bone Marrow Registry. Sometimes there may be a wait to find a good unrelated donor match. There are two ways of collecting stem cells from the donor; bone marrow harvesting and stem cell harvesting.
High-dose chemotherapy
In the first stage of treatment you will receive high-dose chemotherapy and or radiotherapy, also called conditioning chemotherapy/radiotherapy. This chemotherapy destroys as many cancer cells as possible that are still in your body after you have completed your standard-dose treatment. Unfortunately, it also destroys other blood cells, significantly reducing your blood count (the levels of blood cells in your blood). Your team will see you every day and monitor you closely during the high-dose treatment.
Allogeneic transplantation
The next step is to receive your donor’s bone marrow or stem cells through a cannula, this is similar to a blood or platelet transfusion. Your new source of stem cells will take approximately 10-21 days to establish and begin to develop (depending on the treatment you received).
You will need a number of tests to make sure that you are ready for your allogeneic stem cell transplant.
These may include:
- Routine blood tests
- MUGA (multiple gated acquisition)
- GFR (glomerular filtration rate)
- Bone marrow aspirate and trephine
- CT scan (computerised tomography)
- PET scan (positron emission tomography)
Your consultant will tell you what to expect and how to prepare for these tests.
As chemotherapy and radiotherapy kill the rapidly dividing cells in the bone marrow, there will be a drop in your blood count. During this time you are particularly vulnerable to infection, bleeding and anaemia. You will need to remain in hospital during this time. The focus of our care will be to support you and we will monitor you closely.
Allogeneic bone marrow or stem cell transplant Consultants
Dr Premini Mahendra
Haematology
Dr. Varun Mehra
Haematology
Dr Panagiotis Kottaridis
Haematology
Dr Kirit Ardeshna
Haematology
Our Allogeneic bone marrow or stem cell transplant locations
University College Hospital Private Care
Grafton Way Building, 1 Grafton Way WC1E 6AG London
The Christie Private Care
Wilmslow Road M20 4BX Manchester
Patient stories
Yvette's story: From back pain to hip replacement surgery
Yvette (54) a journalist from Kent, started experiencing pain in her hip seven years ago in 2015. An ex-national gymnast who had been incredibly active and flexible her whole life, Yvette felt concerned about the growing discomfort impacting her quality of life, and so sought help from her GP.
A new hip and straight back into the spin of things
Michael's MAKO hip surgery to treat his arthritis
73 year-old Michael, an avid walker and charity worker, was diagnosed with arthritis in January 2021. After facing long waiting times and increasing pain that was becoming more frequent, he started to look elsewhere for treatment.
This content is intended for general information only and does not replace the need for personal advice from a qualified health professional.